Sympathomimetic poisonings are commonplace to the Emergency Department . This toxidrome is going to present with increased sympathetic nervous system stimulation. The classic sympathomimetic syndrome is a fight or flight response:

  • Tachycardia
  • Hypertension
  • Mydriasis
  • Diaphoresis
  • Hyperthermia
  • Agitation

Sources include nonprescription sympathomimetic agents include the over-the-counter cold agents (containing ephedrine), street drugs (e.g., cocaine, amphetamines, methamphetamine), dietary supplements (ephedra), and illicit designer drugs (e.g.MDMA, “ecstasy”)

Treatment: sedation, hydration, and treatment of complications such as rhabdomyolysis and hyperthermia. Often supportive treatment alone is necessary for mild ingestions. Benzodiazepines can be useful in this toxidrome. Refer to toxbase for more detailed information