Quality Checklist for Randomized Clinical Trials:

1] The study population included or focused on those in the emergency department.
2] The patients were adequately randomized.
3] The randomization process was concealed.
4] The patients were analyzed in the groups to which they were randomized.
5] The study patients were recruited consecutively (i.e. no selection bias).
6] The patients in both groups were similar with respect to prognostic factors.
7] All participants (patients, clinicians, outcome assessors) were unaware of group allocation.
8] All groups were treated equally except for the intervention.
9] Follow-up was complete (i.e. at least 80% for both groups).
10] All patient-important outcomes were considered.
11] The treatment effect was large enough and precise enough to be clinically significant.
12] Financial conflicts of interest.